 Bruins |  Hampus Lindholm | D | Injured Reserve | Groin Injury | 3 Weeks | 2025-11-19 |
 Devils |  Jayden Struble | D | Sidelined | Strained Left Knee Injury | Day-to-Day | 2025-11-03 |
 Jets |  Jack Thompson | D | Sidelined | Torso Injury | Day-to-Day | 2025-11-05 |
 Lightning |  Filip Hronek | D | Sidelined | Left Hand Injury | Day-to-Day | 2025-11-04 |
| Lightning |  Kailer Yamamoto | C/RW | Sidelined | Sports Hernia Injury | 1 Week | 2025-11-07 |
 Maple Leafs |  Declan Chisholm | D | Long Term Injured Reserve | Lower Body Injury | 3 Weeks | 2025-11-19 |
 Penguins |  Lucas Carlsson | D | Sidelined | Right Hand Injury | Day-to-Day | 2025-11-05 |
 Predators |  Rory Kerins | C | Sidelined | Left Leg Injury | Day-to-Day | 2025-11-03 |
 Rangers |  Jet Greaves | G | Sidelined | Exhaustion | Day-to-Day | 2025-11-03 |
 Sharks |  Charlie McAvoy | D | Long Term Injured Reserve | Bruised Left Foot Injury | 3 Months | 2026-01-15 |
 Stars |  Jacob Fowler (R) | G | Injured Reserve | Right Hand Injury | 2 Weeks | 2025-11-16 |
 Wild |  Trevor Moore | LW | Sidelined | Left Hand Injury | Day-to-Day | 2025-11-03 |
